Once quarterback Trevor Siemian went down, the Denver Broncos never panicked.

Neither did replacement Brock Osweiler as he recorded three touchdowns in Denver’s 25-13 road win against Indianapolis.

Denver started in a 10-0 hole through a quarter-plus of football. Indianapolis quarterback Jacoby Brissett ran for a seven-yard touchdown in the first and kicker Adam Vinatieri followed up the score with a 45-yard field goal with 6:33 to go in the second quarter. Osweiler used his legs for the Broncos’ first touchdown, rushing into the end zone for an 18-yard touchdown with 1:18 to play in the half.

The Denver defense locked down in the Colts in the second half after giving up a 39-yard field goal by Vinatieri early in the third. Osweiler threw a pair of touchdown passes, a 22-yarder to Cody Latimer and a 54-yard strike to Jeff Heuerman, giving Denver a 22-13 advantage after three quarters.

Osweiler was 12-of-17 passing for 194 yards and two touchdowns. Tailback C.J. Anderson carried the ball 30 times for 158 yards.

Denver limited Brissett to 17 completions on 30 attempts for 158 yards. Indianapolis only picked up 228 yards of total offense.

The Broncos (5-9) host the Washington Redskins next Sunday at noon with pregame at 10:05 am on Real Country 101.7.